The news comes just one day after General Motors closed its transmission plant, pulling out of the city after 90 years.
The Ford workers have been told they will be laid off beginning Nov. 1.
Ford has decided to eliminate one shift at the plant.
However, as that happens, the automaker plans to begin another shift at the newly rebuilt Essex engine plant, also located in Windsor.
The net loss of jobs in that move will be 388.
"We were aware we were going to lose the shift, they just didn't have the numbers," said Dan Cassidy, president of CAW Local 200, representing Ford workers.
"Now that they've got the numbers, we had to make sure that our members are aware of what's going on and how that will affect them."
GM left 500 people out of work when it closed its transmission plant on Wednesday.
